Structure-Based Design and Optimization of Novel PHGDH Inhibitors for Overcoming Erlotinib-Resistant Lung Cancer

Success examples

Wu X., Tang S., Yan Y., Cao X., Cen Y., Lan X., Zhu Y., Shi D-Y., Lin G-Q., Tian P., Huang M., Gao D.

J Med Chem. 2026. Online ahead of print.

PHGDH Inhibitor PHGDH Inhibitor