Success examples
Tumor metabolic adaptation induced by L-asparaginase reveals a vulnerability to PARP1/2 inhibitor in B-cell lymphomas

Aussel A., Nemazanyy I., Vandenberghe A., Meola P., Dorat N., Paul R., Habbouche L., Exposito L., Nottet N., Petrilli V., Chiche E., Mounier N., Marchetti S., Chaveroux C., Ricci J-E., Chiche J. 

Nat Commun 2026. Online ahead of print.

PHGDH Inhibitor
DOI
PubMed
Success examples
An Allosteric Assay for Identifying Ligands Binding to β2 Adrenergic Receptor by Surface-Enhanced Raman Scattering (SERS)-Active Nanoparticles

Wang Y., Lu N., Wu P., Chu Y., Xing Y., Wang J., Zhao X.

Anal Chem. 2026, 98(6):4895-4904.

β2AR agonist
DOI
PubMed
Success examples
KAT2A contributes to premature ovarian insufficiency by activating the P38/MAPK signaling pathway to drive granulosa cell dysfunction

Li J., Liu Y., Huang L., Yu Y., Xu A., Luo T., Zheng L., Le M., Xu L.

Biol Reprod. 2026, ioag038. Online ahead of print.

P38 MAPK Inhibitor
DOI
PubMed
Success examples
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids

van Knippenberg S. S. F. A., Tryfonos M., De Busscher J., Solis M., Lorent C., Girard O., Poovathingal S., Wojno M., Khodeer S., De Clercq J., Mikorska A., Smeers I., Wigerinck E., Meynen Y., Voet T., David L., Van de Velde H., Pasque V.

bioRxiv 2025. 12.01.691499.

SMARCA2/4 PROTAC
DOI
Success examples
Nanoencapsulated senotherapeutic compounds targeting connexin-43 for enhanced wound healing

Rodríguez-Candela Mateos M., García-Fernández J., Saraiva S. M., Grimaudo M. A., Alijas S., Escudero A., Varela-Eirín M., Pérez Cano J., Acea Nebril B., Barrio L. C., Mayan M. D., de la Fuente M.

iScience 2026, Volume 29, Issue 2, 114547.

P38 MAPK Inhibitor
DOI
Success examples
p38 inhibition restores chemosensitivity of tumor cells by disrupting oligomerized breast cancer resistance protein membrane trafficking

Pan Y., Zhu Z., Zhu Y., Hu T., Zhang Z., Fan H., Yu S., Wei Z., Wang A., Lu Y., Chen W.

iScience. 2025, 29(1):114359.

P38 MAPK Inhibitor
DOI
PubMed