Success examples
Glucocorticoid receptor suppresses GATA6-mediated RNA polymerase II pause release to modulate classical subtype identity in pancreatic cancer

Ekstrom T. L., Rosok R. M., Abdelrahman A. M., Parassiadis C., Manjunath M., Dittrich M. Y., Wang X., Kutschat A. P., Kanakan A., Rajput A., Schacherer N., Lukic T., Carlson D. M., Thiel J., Kopp W., Stroebel P., Ellenrieder V., Gaedcke J., Dong M., Najafova Z., Truty M. J., Hessmann E., Johnsen S. A. 

Gut 2025, 74(7):1112-1124.

Glucocorticoid Receptor (GR) Agonist
DOI
PubMed
Success examples
Identification of 5-amino-1,3,4-thiadiazole appended isatins as bioactive small molecules with polypharmacological activities

Azam U., Humayun W. A., Avathan Veettil A. K., Liu Y., Hastürk O., Jiang M., Sievers S., Wu P., Naseer M. M.

RSC Med. Chem. 2025.

CCR10 antagonist
DOI
Success examples
Characterization of a pleomorphic rhabdomyosarcoma cell line

Stickler S., Lang C., Rieche M., Eggerstorfer M-T., Hohenegger M., Hochmair M., Hamilton G.

Sci Rep. 2025, 15(1):2893.

GSK-3 inhibitor
DOI
PubMed
Success examples
A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis

Kent A., Yee Mon K. J., Hutchins Z., Putzel G., Zhigarev D., Grier A., Jia B., Kortlever R. M., Barbet G., Evan G. I., Blander J. M.

Nat Immunol. 2025, 26(1):53-67.

KRAS switch I/II pocket inhibitor
DOI
PubMed
Success examples
Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastoma

De Martino M., Daviaud C., Minns H. E., Lazarian A., Wacker A., Costa A. P., Attarwala N., Chen Q., Choi S-W., Rabadàn R., McIntire L. B. J., Gartrell R. D., Kelly J. M., Laiakis E. C., Vanpouille-Box C.

Cancer Lett. 2023, 570:216329.

FAS inhibitor
DOI
PubMed
Success examples
The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells

Wolf G., Craigon C., Teoh S. T., Essletzbichler P., Onstein S., Cassidy D., Uijttewaal E. C. H., Dvorak V., Cao Y., Bensimon A., Elling U., Ciulli A., Superti-Furga G.

Cell Chem Biol. 2025, 32(2):291-306.e6.

BET PROTAC
DOI
PubMed