Success examples Discovery of Highly Potent, Selective, and Liver-Targeting HSD17B13 Inhibitor with Robust In Vivo Anti-MASH Activity Chen L., Liang Z., Mao J., Liao Z., Liu Y., Ou D., Liu C., Li Z.J Med Chem. 2025, 68(11):11127-11148. Share page DOI PubMed
Success examples Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID Shrestha S., Maitland M. E. R., Jing L., Duan S., Nie D. Y., St-Germain J., Barsyte-Lovejoy D., Arrowsmith C. H., Raught B.bioRxiv 2025, 14.648778. BRD7/BRD9 PROTAC SMARCA2 PROTAC Share page DOI
Success examples Oxidation of low-density lipoprotein by hemoglobin causes pulmonary microvascular endothelial barrier dysfunction through lectin-like oxidized LDL receptor 1 Meegan J. E., Riedmann K. J., Gonski S., Douglas J. S., Bogart A. M., Ware L. B., Bastarache J. A.Am J Physiol Lung Cell Mol Physiol. 2025, 328(5):L748-L755. LOX-1 inhibitor Share page DOI PubMed
General literature Empowering research in chemical biology and early drug discovery - an update from the European research infrastructure EU-OPENSCREEN Harmel R. K., Miletic T., Herzog K., Stechmann B.SLAS Discov. 2025, 32:100228. Share page DOI PubMed
Success examples The lung microvasculature promotes alveolar type 2 cell differentiation via secreted SPARCL1 Panza P., Kim H-T., Lautenschläger T., Piesker J., Günther S., Alayoubi Y., Cleaver O., Looso M., Stainier D. Y. R.Stem Cell Reports. 2025, 20(4):102451. IKKβ inhibitor Share page DOI PubMed
Success examples Spatio-temporal control of mitosis using light via a Plk1 inhibitor caged for activity and cellular permeability von Glasenapp V., Almeida A. C., Chang D., Gasic I., Winssinger N., Gotta M.Nat Commun. 2025, 16(1):1599. PLK1 inhibitor Share page DOI PubMed
