Success examples
The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells

Wolf G., Craigon C., Teoh S. T., Essletzbichler P., Onstein S., Cassidy D., Uijttewaal E. C. H., Dvorak V., Cao Y., Bensimon A., Elling U., Ciulli A., Superti-Furga G.

Cell Chem Biol. 2025, 32(2):291-306.e6.

Success examples
Recent advances in the development of 17beta-hydroxysteroid dehydrogenase inhibitors

Poirier D.

Steroids. 2025, 213:109529.

Success examples
Targeting of MMP-13 prevents aortic aneurysm formation in Marfan mice

Zimmermann LM. A., Furlan A.G., Mehrkens D., Geißen S., Zuk A.V., Pryymachuk G., Pykarek N., van Beers T., Sonntag-Bensch D., Marzi J., Schenke-Layland K., Brinckmann J., Zigrino P., Grandoch M., Baldus S., Sengle G.

bioRxiv 2022, 518511.

Success examples
Super-Enhancer Dysregulation in Rhabdoid Tumor Cells Is Regulated by the SWI/SNF ATPase BRG1

Jones C. A., Wang J., Evans J. R., Sisk H. R., Womack C. B., Liu Q., Tansey W. P., Weissmiller A. M.

Cancers (Basel). 2024, 16(5):916.

Success examples
Enhancement of Intracellular Cholesterol Efflux in Chondrocytes Leading to Alleviation of Osteoarthritis Progression

Lee G., Yang J., Kim S. J., Tran T. T., Lee S. Y., Park K. H., Kwon S. H., Chung K. H., Koh J. T., Huh Y. H., Seon J. K., Kim H. A., Chun J. S., Ryu J. H.

Arthritis Rheumatol. 2025, 77(2):151-162.

Success examples
Fluorophore-Labeled Pyrrolones Targeting the Intracellular Allosteric Binding Site of the Chemokine Receptor CCR1

Toy L., Huber M. E., Lee M., Alonso Bartolomé A., Ortiz Zacarías N. V., Nasser S., Scholl S., Zlotos D. P., Mandour Y. M., Heitman L. H., Szpakowska M., Chevigné A., Schiedel M.

ACS Pharmacol Transl Sci. 2024, 7(7):2080-2092.