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If you've already used one of our molecules, please leave a review.
BI‑9222 is a potent and selective Phosphoinositide-3-kinase gamma (PI3Kγ) inhibitor that modulates GPCR‑driven immune signaling, regulating cell migration, inflammation, and immune responses. BI‑9183 is available as its negative control.
Inhibition of PDE9 is expected to restore physiological cGMP levels in neurons, thereby enhancing NMDA receptor signaling and synaptic plasticity. BI 409306 (osoresnontrine) is a highly selective oral PDE9 inhibitor and BI-8777 an inactive analog which serves as a negative control.
Vanin 1 and vanin 2 regulate redox homeostasis and play essential roles in maintaining oxidative balance and modulating inflammation. For further research, we offer BI-4122, a dual vanin 1/2 inhibitor optimized for intravenous and oral administration.
mGluR1 PAMs restore cortical inhibitory tone and improve cognition in models of NMDA receptor hypofunction. To support research into mGluR1 function, we offer BI02982816 and its optimized reiteration, BI-1752 — two selective mGluR1 PAMs.
BI-3972 is a potent and selective small-molecule agonist of the calcium-activated potassium channel Slowpoke 1 (SLO-1), which is ubiquitously expressed in metazoans and involved in diverse physiological processes. The structurally related analog BI-4083 serves as a negative control.