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mGluR2 Positive Allosteric Modulator BI-4737

BI-4737 is a Positive Allosteric Modulator (PAM) of the metabotropic glutamate receptor 2 (mGLuR2), a neuronal GPCR negatively coupled to adenylyl cyclase.

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opnMe compounds deepened my understanding of cancer cell spreading, illuminating crucial molecular mechanisms. Grateful for their contribution in advancing my research.

Professor of Experimental Biology, University of Udine, Italy

From the generous support of opnMe, we were able to use an expensive compound, BI-653048, for free! This made critical experiments in cell lines and patient-derived xenografts possible. The process of ordering and receiving compounds was seamless and easy and I highly encourage more scientists to engage in open science.  

PhD candidate, Robert Bosch Center for Tumor Diseases, Stuttgart

Through interactions with the SGC, we received a well-characterized donated chemical library, including BI-653048, with the generous support of opnMe. This was invaluable to our project, enabling extensive in vitro studies and crucial in vivo experiments. Without opnMe’s support, this would have been very difficult. We are truly grateful!

Scientific Director, Robert Bosch Center for Tumor Diseases, Stuttgart

I found the opnMe team easy to work with, helpful and open in our discussions. Our request for one of their compounds was quickly acted upon and dispatched to us with little difficulty. And we are based in Australia. I am looking forward to continuing our connection as our research develops.

Professor, Head of Smiling for Smiddy Cell Cycle Group, Mater Research Institute, Australia

The MMP-13 inhibitor’s prompt delivery, along with the collaborative expertise and exceptional support from opnMe, significantly accelerated my preclinical trial work, enhancing both the research speed of my PhD thesis and the quality of my publications.

Postdoctoral Researcher, University Hospital Cologne

The opnMe innovation portal has been an invaluable resource in my scientific work. Its easy-to-use platform, comprehensive data, and support for collaboration provide great benefits, making it a valuable tool for any scientist looking to advance their research.

Postdoctoral Researcher, Otto Loewi Research Center, Medical University of Graz, Austria

I tested BI-9740, obtained for free in my experiments. This significantly advanced my research in anti-proteolytic therapy upstream of pro-inflammatory neutrophil serine proteases by blocking their maturating enzyme, cathepsin C. Their support has been crucial.

Professor, Head of the Cardiac Surgery Laboratory, Heidelberg University Hospital

Using opnMe's MMP-13 inhibitor, I was able to advance my pre-clinical research on protecting cartilage from progressive degeneration.

Professor, Institute of Nanoscience and Technology (INST), India

opnMe has been an invaluable resource for our research and outputs, providing quick access to a Syk inhibitor with a seamless application process. I fully endorse the opnMe platform as a trusted means of advancing scientific discovery, and highly advise other scientists to consider using it.

Professor, Director of Research, Inserm, France

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