Success examples
Aurora B kinase inhibition intensifies cisplatin cytotoxicity in MCF7 breast cancer cells

Askan R., Gundogdu R.

EJM. 2024, 63(3):410-21.

Aurora B inhibitor
DOI
Success examples
RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade

Nokin M-J., Mira A., Patrucco E., Ricciuti B., Cousin S., Soubeyran I., San José S., Peirone S., Caizzi L., Vietti Michelina S., Bourdon A., Wang X., Alvarez-Villanueva D., Martínez-Iniesta M., Vidal A., Rodrigues T., García-Macías C., Awad M. M., Nadal E., Villanueva A., Italiano A., Cereda M., Santamaría D., Ambrogio C.

Nat Commun 2024, 15(1):7554.

SOS1::KRAS inhibitor
DOI
PubMed
General literature
Chemical coverage of human biological pathways

Kwak H. A., Liu L., Tredup C., Röhm S., Prinos P., Böttcher J., Schapira M. 

Drug Discov Today 2024, 29(10):104144.

DOI
PubMed
Success examples
Discovery of Potent SOS1 PROTACs with Effective Antitumor Activities against NCI-H358 Tumor Cells In Vitro/In Vivo

Pang X., Cui D., Lv B., Wang C-Y.

J Med Chem. 2024, 67(2):1563-1579.

SOS1::KRAS inhibitor
DOI
PubMed
Success examples
HIF1α is involved in radiation-induced DNA damage repair and anti-apoptotic pathways in pancreatic ductal adenocarcinoma

Tu K. J., Roy S. K., Sawant A., Shukla H. D.

Cancer Research 2023, Volume 83, Issue 7_Supplement.

KRAS switch I/II pocket inhibitor
DOI