Got questions about opnMe®?

With our latest opnMe call, we offer a collection of ~ 900 human samples from the 1,000 Genomes Project sequenced using Oxford Nanopore Technology (ONT) free of charge and sharing it with data scientists across the globe to foster open science. The data set is unique as the usage of the ONT reads allows the distinction between DNA methylation and hydroxy-methylation patterns, two major methylation states. This allows to address specific questions related to both types of DNA methylations, linking them to quantitative trait loci and pathological disease mechanisms. Access to this unique dataset with a size of 550 TB will be provided to a limited number of successful applications, depending on the quality of their proposals. Data will be shared based on an open access creative commons license (CC BY-NC 4.0). Of note is that all results obtained with this dataset will be fully owned by the respective data analysts and we encourage to publish results independently.

To request access to the ONT dataset from the 1,000 Genomes Project that comprises of ~ 900 human samples, please share your proposal using our submission template, describing your data analytics plan. All incoming proposals will be evaluated after the final submission date, September 19, and, upon approval, the whole data package will be made available to chosen applicants. Please note that the resulting data package has a size of 550 TB and will be shared in one run. Access to an appropriate data management infrastructure to host a large data set and to process it will be a requisite to participate in this call.

Please use our answer submission template to provide a 3 - 4 page non-confidential proposal (available for download on the following site).

If confidential data exists that would strengthen the proposal, please indicate that information is available to share under a Confidential Disclosure Agreement (CDA). If we find the non-confidential concept proposal sufficiently interesting, we will execute a CDA for confidential discussions.

• A well-structured proposal outlining a novel approach that includes usage of our data.
• The proposal should contain only non-confidential information of your intended research objectives, proposed analysis, anticipated timelines, and planned start of the project.
• Please note that analyses using the data library must commence within the next 12 months to become eligible for this opnMe call.
• Any proposals focusing on target identification and disease understanding would be preferred.
• Access to long term storage with capacity for data sharing and backup. Proposals that further dissemination of the data publicly will be prioritized.
• The proposal and resulting publications should acknowledge Boehringer Ingelheim as the owner of the data.
• Please note that anyone using the material must provide credit to the original authors and indicate any changes that were made (CC-BY-NC 4.0).

Yes. Boehringer Ingelheim covers all costs of the initial data transfer.

As part of this call, no additional budgetary funding will be provided. Rather, we intend to incentivize innovative data analyses by providing our rich dataset free of charge.

Boehringer Ingelheim scientists with relevant expertise will start with the review of all incoming proposals after the final submission date on September 19, 2024. We aim to finalize our review by end of October 2024.

No. Applications will be shared inside Boehringer Ingelheim amongst a team of scientists for the sole purpose of reviewing the proposals. Any submissions will not be visible to, or shared with, scientists from other institutions.

There is no obligation to share any data with us, however, resulting publications should acknowledge Boehringer Ingelheim as the owner of the data. Please cite opnMe.com if you publish any studies using our data using the following copy: „opnMe - Boehringer Ingelheim Open Innovation Portal. 2024. Boehringer Ingelheim International. [Available at https://www.opnme.com/, last accessed: [“Enter date”].”

All IP generated based on the proposed research project remains with you.