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BI-9564 binds with high affinity to BRD9 (KD( ITC) = 14 nM), displays good cellular potency and an excellent selectivity versus most BET family members.
BI-4394 is a potent and highly selective inhibitor of MMP-13 that can be used as tool compound to test biological hypotheses in vitro.
Our compound is the first small molecule inhibitor of the Chemokine receptor CCR10.1-3 It is a potent and selective compound and suitable for in vivo validation.
CCR1 is a key chemokine receptor for human monocyte/macrophage chemotaxis. BI-639667 blocks influx of pro-inflammatory cells to the site of inflammation.
BI 831266 is a potent and selective Aurora B inhibitor that inhibits cell proliferation and could be used as a tool compound for testing biological hypotheses.