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VZ185 is a first-in-class low-molecular-weight VHL-based PROTAC (proteolysis-targeting chimera) degrader of the BAF/PBAF complexes subunits BRD7 and BRD9.
Prodrug BIIL 284 represents an excellent compound to study the effect of LTB4 receptor antagonism in vivo. After p.o.
BIIL 315 is a highly potent LTB4 receptor antagonist (Ki = 1.9 nM).1 It is the active metabolite of the in vivo tool compound BIIL 284 and is the ideal tool to study LTB4 antagonism in vitro.
BI-0588 is one of the most potent and specific allosteric inhibitors of Hepatitis C Virus (HCV) polymerase known, as demonstrated by its cell-based antiviral replicon activity in the single-digit nM range for genotype(GT)-1.
BI-4752 and BI-3234 are potent 5-HT2C receptor agonists, with good in vivo PK profiles in rodents. BI-4752 and BI-3234 reduced food intake in db/db mice at a 100 mg/kg dose, and body weight was decreased over a 28 days period.