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Due to its high potency and good physicochemical properties, suitable selectivity profile and low toxicity, BI 1002494 is an excellent tool to explore SYK functions in vitro and in vivo.
BI-1935 is a potent and selective small molecule inhibitor of Soluble epoxide hydrolase (sEH). In a biochemical binding assay h-sEH it shows an IC50 of 7 nM and is also highly active in a cellular Hep G2-DHET assay format (IC50 < 1 nM).