20 October 2025
The demand for innovative chemical transformations has grown significantly as researchers strive to develop therapies targeting diseases with challenging biological mechanisms. Modern drug discovery faces substantial hurdles due to the limited availability of robust and versatile chemical building blocks, which are essential for synthesizing highly functionalized and structurally diverse molecules. Unfortunately, the high cost and restricted access to complex building blocks hinder the validation of new methodologies in medicinally relevant contexts. This leads to a vicious cycle where the lack of suitable building blocks limits methodology development, and unvalidated methods restrict their application in drug discovery. Breaking this pattern is crucial for advancing synthetic chemistry and addressing challenging therapeutic targets.
To incentivizing modern approaches, we are launching the "Boehringer Ingelheim ChemKit" initiative to accelerate innovation in synthetic chemistry by providing open access to high-quality, structurally diverse, and drug-relevant building blocks. These building blocks are designed to stimulate research on novel synthetic methodologies, enabling scientists to overcome current limitations in chemical transformations.
As an expert, please submit your proposal in response to the following question:
Presented with a selection of chemical building blocks, how would you validate chemical transformations for the rapid synthesis of complex chemical structures?
We will review submitted proposals based on scientific merit, feasibility, and potential impact. Our aim is to foster a vibrant community of researchers working together to push the boundaries of chemical synthesis. Recipients of the collection will gain access to 500 mg of each building block in the ChemKit.
Submit your ideas now! Proposals will only be accepted if received through December 10, 2025, 11:59 pm PST.
No registration required for download
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About our call for “Molecules for Collaboration”:
On opnMe, we now offer “The Boehringer Ingelheim ChemKit”, a collection of high-quality, structurally diverse, and drug-relevant building blocks to validate chemical transformations for the rapid synthesis of complex chemical structures. Submit your proposals through December 10, 2025. Learn more…
About opnMe:
opnMe.com, the open science portal of Boehringer Ingelheim, fosters science and collaboration initiatives in areas of high unmet medical need. Our molecules are provided to the scientific community either free of charge as “Molecules to Order” or applied for via scientific research submissions as “Molecules for Collaboration”. With our “opn2EXPERTS” and “techMATCH” programs, we enlist scientific advice on key scientific topics to fuel further drug discovery and deliver novel solutions that benefit unmet patient needs. Our "opn2TALENTS" postdoc grants at one of our research sites offer opportunities for high-level talents to propose innovative approaches for precisely defined scientific questions.