2 March 2026
Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that generate phosphatidylinositol-based second messengers, which regulate essential cellular processes such as growth, survival, and motility. Among the PI3K family, Class I PI3Ks are the best characterized and consist of four catalytic isoforms: PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, each with distinct physiological roles. PI3Kγ is predominantly expressed in innate immune cells, where it integrates signals from G-protein-coupled receptors to regulate chemotaxis, inflammatory activation, and effector functions. Additionally, PI3Kγ contributes to tumor progression by promoting immunosuppressive myeloid phenotypes and has been shown to serve as a cancer intrinsic survival factor in leukemia as part of preclinical studies.
To support novel discoveries in PI3K research, we offer BI-9222, a specific PI3Kγ inhibitor, and its inactive analog, BI-9183, free of charge with full ownership of your results. We encourage you to publish your findings and contribute to the advancement of PI3K science.
No registration required
Subscribe to our newsletter to stay updated as we add new molecules to opnMe.com.
About BI-9222:
BI-9222 is a potent PI3Kγ inhibitor with sub-nanomolar in vitro activity. It shows excellent selectivity over PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ. BI-9222 exhibits good hepatocyte stability and clearance in rats and is suitable for in vivo experiments.
About opnMe:
opnMe.com, the open innovation portal of Boehringer Ingelheim, fosters science and collaboration initiatives in areas of high unmet medical need. As part of our “Molecules to Order” pillar, we share well-characterized tool compounds free of charge with no IP strings attached. With our current “opn2EXPERTS” call on the role of TLR5 in tumor immune evasion, we enlist scientific advice on key biologic issues to fuel further drug discovery and deliver novel solutions that benefit unmet patient needs. Our current opn2TALENTS PostDoc grant on lymphatic dysfunction in chronic lung diseases , provide an opportunity for high-caliber talents to pitch their scientific approaches for well-defined research questions to conduct their research at one of our discovery research sites.