21 May 2025
SGC, DCP, and opnMe: The journey of our glucocorticoid receptor agonist and how it impacted independent research
Tuesday, June 24th, 2025
8:00 am PST | 11:00 am EST | 4:00 pm GMT | 5:00 pm CET
Duration: 60 minutes including interactive session
Join our live online seminar and discover how academic researchers, driven by curiosity to understand disease processes, uncovered fundamental mechanisms promoting cancer progression. By applying their disease-specific screening system and leveraging open innovation, they identified the glucocorticoid receptor as a key player in pancreatic cancer. This discovery opened the door to deeper investigations, revealing the receptor’s influence on tumor growth in specific pancreatic cancer subtypes by using a well-characterized glucocorticoid receptor agonist from opnMe.
Learn more about our glucocorticoid receptor agonist, BI-653048, and its availability through open innovation initiatives such as the Structural Genomics Consortium (SGC)1, the Donated Chemical Probes (DCP)2 program, and opnMe. Susanne Müller-Knapp and Florian Montel will reveal how these initiatives are enabling academic innovations. Thomas Ekstrom will focus on the science of glucocorticoid receptor signaling and share how open innovation platforms enabled its functional characterization in pancreatic cancer subtypes.
As part of this interactive seminar, engage with the experts and find inspiration for your own research.
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About opnMe:
opnMe.com, the open science portal of Boehringer Ingelheim, fosters science and collaboration initiatives in areas of high unmet medical need. Our molecules are provided to the scientific community either free of charge as “Molecules to Order” or applied for via scientific research submissions as “Molecules for Collaboration”. With our “opn2EXPERTS” and “techMATCH” programs, we enlist scientific advice on key scientific topics to fuel further drug discovery and deliver novel solutions that benefit unmet patient needs. Our "opn2TALENTS" postdoc grants at one of our research sites offer opportunities for high-level talents to propose innovative approaches for precisely defined scientific questions.
About opnMe online seminars:
We invite you to watch the recordings of our previous online seminars that focus on other molecules from opnMe:
- CatC-in-human-disease: Novel roles of Cathepsin C in human disease
- MMP-13 antagonist: Assessing MMP-13 functions in osteoarthritis and aortic aneurysm
- PROTAC ACBI1: Illuminating the role of SMARCA2/4 in childhood cancer
- BCL6 Degrader: Elucidating the mechanism of small molecule induced protein degradation
References:
- Home | Structural Genomics Consortium
- Donated chemical probes | Structural Genomics Consortium
- Ekstrom T. L., Rosok R. M., Abdelrahman A. M., Parassiadis C., Manjunath M., Dittrich M. Y., Wang X., Kutschat A. P., Kanakan A., Rajput A., Schacherer N., Lukic T., Carlson D. M., Thiel J., Kopp W., Stroebel P., Ellenrieder V., Gaedcke J., Dong M., Najafova Z., Truty M. J., Hessmann E., Johnsen S. A. Glucocorticoid receptor suppresses GATA6-mediated RNA polymerase II pause release to modulate classical subtype identity in pancreatic cancer Gut. 2025, Jan 30. DOI: 10.1136/gutjnl-2024-334374.