03 July 2025
SGC, DCP, and opnMe: The journey of our glucocorticoid receptor agonist and how it impacted independent research
The recording of our June 24 opnMe seminar is now available for streaming. Discover how academic researchers used an elegant screening approach, using tools from open innovation platforms such as opnMe, and uncovered a novel fundamental mechanism promoting pancreatic cancer progression. By leveraging BI 653048, opnMe’s well-characterized glucocorticoid receptor agonist, they identified the glucocorticoid receptor as a key player in specific pancreatic cancer subtypes.
Learn more about the availability of BI 653048 through open innovation initiatives such as the Structural Genomics Consortium (SGC)1, the Donated Chemical Probes (DCP)2 program, and opnMe. In this seminar, Susanne Müller-Knapp and Florian Montel reveal how these initiatives are enabling academic innovations. Thomas Ekstrom focuses on the science of glucocorticoid receptor signaling and shares how open innovation platforms enabled its functional characterization in pancreatic cancer subtypes.
Start streaming now and find inspiration for your own research.
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About opnMe:
opnMe.com, the open science portal of Boehringer Ingelheim, fosters science and collaboration initiatives in areas of high unmet medical need. Our molecules are provided to the scientific community either free of charge as “Molecules to Order” or applied for via scientific research submissions as “Molecules for Collaboration”. With our “opn2EXPERTS” and “techMATCH” programs, we enlist scientific advice on key scientific topics to fuel further drug discovery and deliver novel solutions that benefit unmet patient needs. Our "opn2TALENTS" postdoc grants at one of our research sites offer opportunities for high-level talents to propose innovative approaches for precisely defined scientific questions.
About opnMe online seminars:
We invite you to watch the recordings of our previous online seminars that focus on other molecules from opnMe:
- CatC-in-human-disease: Novel roles of Cathepsin C in human disease
- MMP-13 antagonist: Assessing MMP-13 functions in osteoarthritis and aortic aneurysm
- PROTAC ACBI1: Illuminating the role of SMARCA2/4 in childhood cancer
- BCL6 Degrader: Elucidating the mechanism of small molecule induced protein degradation
References:
- Home | Structural Genomics Consortium
- Donated chemical probes | Structural Genomics Consortium
- Ekstrom T. L., Rosok R. M., Abdelrahman A. M., Parassiadis C., Manjunath M., Dittrich M. Y., Wang X., Kutschat A. P., Kanakan A., Rajput A., Schacherer N., Lukic T., Carlson D. M., Thiel J., Kopp W., Stroebel P., Ellenrieder V., Gaedcke J., Dong M., Najafova Z., Truty M. J., Hessmann E., Johnsen S. A. Glucocorticoid receptor suppresses GATA6-mediated RNA polymerase II pause release to modulate classical subtype identity in pancreatic cancer Gut. 2025, Jan 30. DOI: 10.1136/gutjnl-2024-334374.