32
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27 January 2025

The reciprocal interaction between the intestinal tract and the liver, the gut-liver axis, is known to play a crucial role in maintaining hepatic homeostasis and function. Perturbation of this bidirectional crosstalk through an impaired intestinal barrier is observed in chronic liver disease and involves inflammation and tissue remodeling.

79
Molecules for free

20 January 2025

Voltage-gated Na+ channels (Nav1.1 – Nav1.9) are transmembrane proteins involved in the conduction of sodium ions and action potential initiation and propagation. They play a crucial role in the function of excitable tissues in the central nervous system, peripheral nervous system, heart, skeletal muscle, and nociceptive signaling.

54
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02 December 2024

Cancers represent complex ecosystems that include tumor cells and a variety of non-cancerous cells such as immune cells, stroma cells, and other cell types present in the surrounding tissues, all embedded in a modified extracellular matrix. This environment within and around the tumor is known as the tumor microenvironment (TME).

63
Molecules for free

18 November 2024

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that is activated when it binds to ligands from the EGF family. This induces receptor dimerization, tyrosine autophosphorylation, and leads to cell proliferation. It is widely expressed across multiple human tissues, including skin, brain, colon, liver,...

72
Molecules for free

30 September 2024

The Kirsten rat sarcoma viral oncogene homologue (KRAS) is the most mutated oncogene in human cancers. Through opnMe, we offer ACBI3, a first-in-class proteolysis targeting chimera (VHL PROTAC) which arises from a successful collaboration with...

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