41
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6 October 2025

Watch our online seminar to discover how sharing a selective inhibitor via opnMe advanced SOS1-RAS research in novel disease indications. Hear how two academic researchers uncovered novel therapeutic strategies in oncology and diabetes, powered by open science and BI-3406.

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22 September 2025

Fibrosis plays a pivotal role in endometriosis disease progression and associated pelvic pain. Targeting fibrosis in endometriotic lesions may represent a promising therapeutic strategy. However, current preclinical models fail to replicate the chronic fibrosis observed in humans, limiting our ability to fully understand the disease mechanisms.

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18 September 2025

opnMe now offers selectivity data for a subset of initial twelve molecules, in addition to the data already available—all free to access. Researchers can now explore enhanced selectivity profiles generated using the PRESTO-TANGO screen from the Psychoactive Drug Screening Program (PDSP), supporting deeper insights into GPCR interactions.

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26 August 2025

GPR149, an orphan G-protein coupled receptor, might be a promising therapeutic target for psychiatric and obesity-related disorders. Despite its conserved expression across mammalian species, its physiological and functional roles remain poorly understood. Notably, GPR149 is predominantly expressed in the brain, with high levels in regions such as the basal ganglia, which regulate motivation, emotion, and impulsivity—key pathways implicated in psychiatric disorders.

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11 August 2025

In an exclusive interview with opnMe.com, representatives from the Drug Discovery Hub, a pioneering initiative between Imperial College London and the Medical Research Council (MRC) Laboratory of Medical Sciences (LMS), shared insights into their groundbreaking work and the significant role of collaborations in accelerating drug discovery.

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Hear from our collaborators