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29 July 2024

Excessive fructose consumption is associated with metabolic disorders such as obesity, diabetes and non-alcoholic fatty liver disease (NAFLD). Ketohexokinase (KHK) is an enzyme catalyzing the first committed step in fructose metabolism, by...

69
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15 July 2024

The enzyme GTP cyclohydrolase I (GCH1) catalyzes the first and rate limiting step in the biosynthesis of tetrahydrobiopterin (BH4) from GTP. BH4 is a critical cofactor in the degradation of the amino acid phenylalanine, the production of the signaling molecule nitric oxide (NO), as well as the synthesis of the neurotransmitters...

87
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27 June 2024

Watch the recording of our opnMe online seminar from June 20, 2024, and meet the winning team of our opn2EXPERTS call with the goal of finding innovative readouts to analyze the complex neuronal circuits in the brain. Learn about novel technologies...

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36
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21 May 2024

The Kirsten rat sarcoma viral oncogene homologue (KRAS) protein is a small membrane-bound GTPase (GTP hydrolase), acting as a key node in intracellular signaling pathways that are involved in cell growth and survival. Mutations in...

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