20
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18 March 2024

Fibrosis is a pathological feature of many human inflammatory diseases such as pulmonary fibrosis, Crohn’s disease, scleroderma, metabolic-associated steatohepatitis, chronic kidney diseases as well as cancer. Complex multi-dimensional...

46
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4 March 2024

Orexins or hypocretins are two neuropeptides (OX-A and OX-B) that are synthesized in the hypothalamus, and serve as ligands for the G protein-coupled receptors OX1 and OX2. While the role of orexins was initially thought to be limited to the regulation of...

52
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19 February 2024

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system (CNS), exerting its effects via two classes of receptors, GABAA and GABAB. GABAA receptors (GABAARs) are ligand-gated ion channels typically...

27
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5 February 2024

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease with a high mortality rate, characterized by scarring of the lungs, which reduces their capacity to transfer oxygen to the bloodstream. Therapeutic options are limited since the...

21
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22 January 2024

GPR88 is a G-protein coupled receptor (GPCR) expressed primarily in the GABAergic medium spiny neurons of the striatum, and to a lesser extent in the cerebral cortex, amygdala, and hypothalamus. Although its exact function and endogenous ligands are...

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