36
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3 March 2025

N-methyl-D-aspartate receptors (NMDARs) are tetrameric ion channels that play critical roles in the development and function of the central nervous system and have been extensively studied. Conventional NMDARs, composed of two GluN1 and two GluN2 subunits, require glutamate and glycine for their activation, which is essential for neuronal plasticity and regulation of synaptic strength.

21
Molecules for free

10 February 2025

The human ATP-binding cassette transporter subfamily C (ABCC) consists of 12 integral membrane proteins. Among them, nine proteins (ABCC1-ABCC6, ABCC10-ABCC12) form the multidrug resistance protein subfamily. These MRP proteins are widely expressed in the body. MRP4, for instance, is expressed in various tissues and organs, including the brain, liver, and kidney.

89
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31 January 2025

As part of a recent collaboration which arouse from one of opnMe’s Molecule for collaboration projects, we had the chance to speak to Carla Castellar Álvarez, scientific manager at Nanomol Technologies in Spain. The company specializes in delivering advanced solutions to obtain high-added value products by particle design and nanoformulation1.

35
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27 January 2025

The reciprocal interaction between the intestinal tract and the liver, the gut-liver axis, is known to play a crucial role in maintaining hepatic homeostasis and function. Perturbation of this bidirectional crosstalk through an impaired intestinal barrier is observed in chronic liver disease and involves inflammation and tissue remodeling.

79
Molecules for free

20 January 2025

Voltage-gated Na+ channels (Nav1.1 – Nav1.9) are transmembrane proteins involved in the conduction of sodium ions and action potential initiation and propagation. They play a crucial role in the function of excitable tissues in the central nervous system, peripheral nervous system, heart, skeletal muscle, and nociceptive signaling.

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