79
Molecules for free

20 January 2025

Voltage-gated Na+ channels (Nav1.1 – Nav1.9) are transmembrane proteins involved in the conduction of sodium ions and action potential initiation and propagation. They play a crucial role in the function of excitable tissues in the central nervous system, peripheral nervous system, heart, skeletal muscle, and nociceptive signaling.

63
Molecules for free

18 November 2024

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that is activated when it binds to ligands from the EGF family. This induces receptor dimerization, tyrosine autophosphorylation, and leads to cell proliferation. It is widely expressed across multiple human tissues, including skin, brain, colon, liver,...

72
Molecules for free

30 September 2024

The Kirsten rat sarcoma viral oncogene homologue (KRAS) is the most mutated oncogene in human cancers. Through opnMe, we offer ACBI3, a first-in-class proteolysis targeting chimera (VHL PROTAC) which arises from a successful collaboration with...

62
Molecules for free

29 July 2024

Excessive fructose consumption is associated with metabolic disorders such as obesity, diabetes and non-alcoholic fatty liver disease (NAFLD). Ketohexokinase (KHK) is an enzyme catalyzing the first committed step in fructose metabolism, by...

69
Molecules for free

15 July 2024

The enzyme GTP cyclohydrolase I (GCH1) catalyzes the first and rate limiting step in the biosynthesis of tetrahydrobiopterin (BH4) from GTP. BH4 is a critical cofactor in the degradation of the amino acid phenylalanine, the production of the signaling molecule nitric oxide (NO), as well as the synthesis of the neurotransmitters...

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