72
Molecules for free

30 September 2024

The Kirsten rat sarcoma viral oncogene homologue (KRAS) is the most mutated oncogene in human cancers. Through opnMe, we offer ACBI3, a first-in-class proteolysis targeting chimera (VHL PROTAC) which arises from a successful collaboration with...

66
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09 September 2024

The Fms-like tyrosine kinase 3 (FLT3) receptor is expressed by bone marrow progenitors at different stages of lymphoid and myeloid development. When the natural ligand binds to the FLT3 receptor, it triggers receptor dimerization...

62
Molecules for free

29 July 2024

Excessive fructose consumption is associated with metabolic disorders such as obesity, diabetes and non-alcoholic fatty liver disease (NAFLD). Ketohexokinase (KHK) is an enzyme catalyzing the first committed step in fructose metabolism, by...

69
Molecules for free

15 July 2024

The enzyme GTP cyclohydrolase I (GCH1) catalyzes the first and rate limiting step in the biosynthesis of tetrahydrobiopterin (BH4) from GTP. BH4 is a critical cofactor in the degradation of the amino acid phenylalanine, the production of the signaling molecule nitric oxide (NO), as well as the synthesis of the neurotransmitters...

23
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01 July 2024

Technical advances in genome sequencing, including long read sequencing, became very popular in recent years allowing us to overcome technical challenges in linking disease phenotypes to nucleotide polymorphisms. For the first time, we are...

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