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08 April 2024

TRPA1 (transient receptor potential cation channel, subfamily A, member 1) is a cation channel expressed in the plasma membrane of multiple cell types, including a sub-population of primary sensory neurons as well as in non-neuronal cells such as...

45
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25 March 2024

Manufacturing peptide medicines involves trifluoroacetic acid (TFA), a chemical that is hard to degrade due to the strength of the carbon-fluoride bond. Through our latest call for proposals, we invite you to propose...

20
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18 March 2024

Fibrosis is a pathological feature of many human inflammatory diseases such as pulmonary fibrosis, Crohn’s disease, scleroderma, metabolic-associated steatohepatitis, chronic kidney diseases as well as cancer. Complex multi-dimensional...

46
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04 March 2024

Orexins or hypocretins are two neuropeptides (OX-A and OX-B) that are synthesized in the hypothalamus, and serve as ligands for the G protein-coupled receptors OX1 and OX2. While the role of orexins was initially thought to be limited to the regulation of...

39
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19 February 2024

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system (CNS), exerting its effects via two classes of receptors, GABAA and GABAB. GABAA receptors (GABAARs) are ligand-gated ion channels typically...

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