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Molecules for free

6 October 2025

Vanin 1 and vanin 2 regulate cellular redox homeostasis and play key roles in maintaining oxidative balance and modulating inflammation. To advance further exploration, we offer BI-4122, a dual vanin 1/2 inhibitor. BI-4122 is optimized for intravenous and oral administration and comes along with BI-9534, an inactive control, to enable robust experimental designs.

27
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6 October 2025

Watch our online seminar to discover how sharing a selective inhibitor via opnMe advanced SOS1-RAS research in novel disease indications. Hear how two academic researchers uncovered novel therapeutic strategies in oncology and diabetes, powered by open science and BI-3406.

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Collaborate with us

22 September 2025

Fibrosis plays a pivotal role in endometriosis disease progression and associated pelvic pain. Targeting fibrosis in endometriotic lesions may represent a promising therapeutic strategy. However, current preclinical models fail to replicate the chronic fibrosis observed in humans, limiting our ability to fully understand the disease mechanisms.

15
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18 September 2025

opnMe now offers selectivity data for a subset of initial twelve molecules, in addition to the data already available—all free to access. Researchers can now explore enhanced selectivity profiles generated using the PRESTO-TANGO screen from the Psychoactive Drug Screening Program (PDSP), supporting deeper insights into GPCR interactions.

5
Molecules for free

8 September 2025

Positive allosteric modulators of mGluR1 restore cortical inhibitory tone and improve cognitive performance in models of NMDA receptor hypofunction. To support ongoing research into mGluR1 function, we now offer two highly selective positive allosteric modulators of mGluR1: BI02982816 and its chemically optimized reiteration, BI-1752.

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Hear from our collaborators