0
Collaborate with us

1 December 2025

Nociplastic pain, a subtype of chronic pain, arises from altered nociception in the absence of clear tissue damage. Its poorly understood pathogenesis and the limited efficacy of current treatments underscore the urgent need for identifying and validating innovative pharmacological approaches that target central neurobiological pathways involved in pain processing.

2
Molecules for free

25 November 2025

By regulating intracellular cGMP levels, phosphodiesterase-9 (PDE9) plays a critical role in neuronal signaling, vascular function, and cell survival. By making our potent, selective, and brain-penetrant PDE9 inhibitor, BI 409306 (osoresonontrine) available to scientists free of charge, we incentivize new research to fully understand the role of the molecule in the context of disease.

9
Collaborate with us

17 November 2025

A large portion of the proteome remains “undruggable” with traditional small molecules and biologics. To expand the druggable target landscape in areas of high unmet medical needs, novel innovative approaches could focus on targeting intracellular mechanisms, such as influencing nuclear translocation, organelle routing, molecular condensates, and spatial-temporal control mechanisms.

26
Discover us

10 November 2025

opnMe now offers a way for scientists to share their feedback directly on the platform. Whether it’s about a molecule you ordered or your overall experience, your input helps us improve and inspires others in the scientific community. Together, let’s make opnMe the best it can be for researchers worldwide.

19
Discover us

3 November 2025

In this interview, Jeffrey Conn highlights Boehringer Ingelheim’s contributions to the discovery and optimization of selective positive allosteric modulators of mGluR1 at Vanderbilt University. He also shares his perspective on how opnMe has changed his perception of the role of open innovation initiatives in advancing drug discovery by making these research tools widely accessible to the scientific community.

Discover us

Hear from our collaborators