63
Molecules for free

18 November 2024

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that is activated when it binds to ligands from the EGF family. This induces receptor dimerization, tyrosine autophosphorylation, and leads to cell proliferation. It is widely expressed across multiple human tissues, including skin, brain, colon, liver,...

51
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5 November 2024

We recently had the chance to speak to Laura-Marie Zimmermann, a former postdoctoral researcher at the University Hospital Cologne, about her experience with opnMe and her interaction with scientists from Boehringer Ingelheim.

46
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28 October 2024

Christian Wolfrum, VP of Research and Professor at the Department of Health Sciences and Technology at ETH Zurich, shared his collaboration experience with Boehringer Ingelheim, enabled through an opn2EXPERTS question on opnMe.

72
Molecules for free

30 September 2024

The Kirsten rat sarcoma viral oncogene homologue (KRAS) is the most mutated oncogene in human cancers. Through opnMe, we offer ACBI3, a first-in-class proteolysis targeting chimera (VHL PROTAC) which arises from a successful collaboration with...

62
Molecules for free

29 July 2024

Excessive fructose consumption is associated with metabolic disorders such as obesity, diabetes and non-alcoholic fatty liver disease (NAFLD). Ketohexokinase (KHK) is an enzyme catalyzing the first committed step in fructose metabolism, by...

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