Success examples
Activation of AMPK & p38MAPK Pathways with a Novel Agonistic Compound in LHCN-M2 Skeletal Muscle Myotubes

Brett R., Beall C., Hodson L., Renshaw D., Turner M.

Endocrine Abstracts 2023, 94 P59.

AMPK Activator
DOI
Success examples
Pharmacological inhibition of the cysteine protease cathepsin C improves graft function after heart transplantation in rats

Liu B., Korkmaz B., Kraft P., Mayer T., Sayour A. A., Grundl M. A., Domain R., Karck M., Szabó G., Korkmaz-Icöz S.

J Transl Med. 2023, 21(1):799.

Cathepsin C inhibitor
DOI
PubMed
Success examples
Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells

Martins-Marques T., Witschas K., Ribeiro I., Zuzarte M., Catarino S., Ribeiro-Rodrigues T., Caramelo F., Aasen T., Carreira I. M., Goncalves L., Leybaert L., Girao H.

Open Biol. 2023, 13(11):230258.

GSK-3 inhibitor
DOI
PubMed
Success examples
Molecular replacement for small-molecule crystal structure determination from X-ray and electron diffraction data with reduced resolution

Gorelik T. E., Lukat P., Kleeberg C., Blankenfeldt W., Mueller R.

Acta Crystallogr A Found Adv. 2023, 79(Pt 6):504-514.

BCL6 inhibitor
DOI
PubMed
Success examples
[3H]UR-JG102-A Radiolabeled Cyclic Peptide with High Affinity and Excellent Selectivity for the Neuropeptide Y Y4 Receptor

Gleixner J., Gattor A. O., Humphrys L. J., Brunner T., Keller M.

J Med Chem. 2023, 66(19):13788-13808.

NPY2R Antagonist
DOI
PubMed
Success examples
SGLT2 inhibitors prevent LPS-induced M1 macrophage polarization and alleviate inflammatory bowel disease by downregulating NHE1 expression

Kim Y. J., Jin J., Kim D-H., Kim D., Lee Y. M., Byun J-K., Choi Y-K., Park K-G.

Inflamm Res. 2023, 72(10-11):1981-1997.

NHE1 inhibitor
DOI
PubMed