Publications

Success examples

Pharmacological inhibition of cathepsin S and of NSPs-AAP-1 (a novel, alternative protease driving the activation of neutrophil serine proteases)

Domain R., Seren S., Jerke U., Makridakis M., Chen KJ., Zoidakis J., Rhimi M,, Zhang X., Bonvent T., Croix C., Gonzalez L., Li D., Basso J., Paget C., Viaud-Massuard MC., Lalmanach G., Shi GP., Aghdassi A., Vlahou A., McDonald PP., Korkmaz B.

Biochemical Pharmacology 2024, 229:116114.

Cathepsin C inhibitor

DOI

PubMed

Success examples

Aurora B kinase inhibition intensifies cisplatin cytotoxicity in MCF7 breast cancer cells

Askan R., Gundogdu R.

EJM. 2024, 63(3):410-21.

Aurora B inhibitor

DOI

Success examples

RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade

Nokin M-J., Mira A., Patrucco E., Ricciuti B., Cousin S., Soubeyran I., San José S., Peirone S., Caizzi L., Vietti Michelina S., Bourdon A., Wang X., Alvarez-Villanueva D., Martínez-Iniesta M., Vidal A., Rodrigues T., García-Macías C., Awad M. M., Nadal E., Villanueva A., Italiano A., Cereda M., Santamaría D., Ambrogio C.

Nat Commun 2024, 15(1):7554.

SOS1::KRAS inhibitor

DOI

PubMed

Success examples

Discovery of Potent SOS1 PROTACs with Effective Antitumor Activities against NCI-H358 Tumor Cells In Vitro/In Vivo

Pang X., Cui D., Lv B., Wang C-Y.

J Med Chem. 2024, 67(2):1563-1579.

SOS1::KRAS inhibitor

DOI

PubMed

Success examples