Success examples
Curcumin monoglucuronide protects cartilage from progressive degeneration by blocking MMP-13

Roy H. S., Kulkarni C., Neethu K. M., Babu A., Arora M., Jayamurugan G., Mandal D., Guha R., Chattopadhyay N., Ghosh D.

Arch Pharm Res. 2025, 48(7-8):765-781.

MMP-13 antagonist
DOI
PubMed
Success examples
CDK8 Inhibition Releases the Muscle Differentiation Block in Fusion-driven Alveolar Rhabdomyosarcoma

Zhang S., Engel K., Fahs A., Malone C. F., Ross K., Just M., Guedes B., Granum D., Oristian K. M., Kovach A., Alexe G., Digiovanni G., Barbar L., Bentley R., Cerda-Smith C., Le Roux O., Mendes E., Zimmerman S. P., Rees M., Roth J., Shern J. F., Wood K. C., Counter C. M., Linardic C. M., Stegmaier K.

bioRxiv. 2025, 2025.07.14.663986.

CDK8 inhibitor
DOI
PubMed
Success examples
Chemical Control of Protease Activity and Gene Expression Using a Biotin-Released Inhibitory Domain

Van Keuren A. M., Simoes C. T., Tucker C. L.

ACS Synth Biol. 2025, 14(8):3065-3077.

BCL6 degrader
DOI
PubMed
Success examples
A comprehensive genetic study of classic Hodgkin lymphoma using circulating tumor DNA

Pirosa M. C., Bruscaggin A., Terzi di Bergamo L., Salehi M., Jauk F., Forestieri G., Bocchetta S., Piffaretti D., Moia R., Cristaldi V., di Trani M., Galimberti G. A., Pini K., Spina V., Giordano C., Condoluci A., Romano I., Annunziata S., Bergesio F., Boldorini R., Borsatti E., Bulian P., Calabretta E., Chauvie S., Corrado F., Crisci S., Cuzzocrea M., De Filippi R., Gerber B., Kurlapski M., Larocca L. M., Merlo E., Rinaldi A., Rodari M., Romanowicz G., Sacchetti G. M., Stathis A., Stüssi G., Zangrilli I., Pinto A., Mazzucchelli L., Gattei V., Zaucha J. M., Santoro A., Hohaus S., Cavalli F., Tzankov A., Carlo-Stella C., Gaidano G., Ceriani L., Zucca E., Rossi D. 

Blood. 2025, 146(10):1207-1224.

BCL6 degrader
DOI
PubMed
Success examples
Mechanical loading induces distinct and shared responses in endothelial and muscle cells and reveals exercise-like molecular profiles

Mäntyselkä S., Niemi E., Ylä-Outinen L., Kolari K., Uusitalo-Kylmälä L., Ortega-Alonso A., Liimatainen R-M., Fachada V., Permi P., Kalenius E., Hulmi J. J., Kivelä R.

bioRxiv 2025, 06.27.661962.

PHGDH Inhibitor
DOI
Success examples
Discovery of a Selective and Potent BCL6 PROTAC with Efficacious Antiproliferative Activity for the Treatment of Diffuse Large B-Cell Lymphoma

Yu X., Liao X., Zhang J., Wang H., Li X., Lu J., Zhou H., Wu M., Jin Y., Zhu X., Xu L., Zeng S., Pan Y., Li J., Che J., Zhou Y., Dong X.

J Med Chem. 2025, 68(19):20180-20206.

BCL6 degrader
DOI
PubMed