Success examples
ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production

Antonello P., Pizzagalli D. U., Foglierini M., Melgrati S., Radice E., Thelen S., Thelen M.

Front Immunol. 2023, 13:1067885.

LTB4 receptor antagonist
DOI
PubMed
Success examples
Senolytic Flavonoids Enhance Type-I and Type-II Cell Death in Human Radioresistant Colon Cancer Cells through AMPK/MAPK Pathway

Russo M., Moccia St., Luongo D., Russo G. L.

Cancers (Basel) 2023, 15(9):2660.

AMPK Activator
DOI
PubMed
Success examples
Deaminative chlorination of aminoheterocycles

Ghiazza C., Faber T., Gómez-Palomino A., Cornella J.

Nat Chem 2022, (1):78-84.

FLAP antagonist
DOI
PubMed
Success examples
Establishment and Evaluation of Dual HDAC/BET Inhibitors as Therapeutic Options for Germ Cell Tumors and Other Urological Malignancies

Burmeister A., Stephan A., Alves Avelar L. A., Müller M. R., Seiwert A., Höfmann St., Fischer F., Torres-Gomez H., Hoffmann M. J., Niegisch G., Bremmer F., Petzsch P., Köhrer K., Albers P., Kurz T., Skowron M. A., Nettersheim D.

Mol Cancer Ther 2022, 21(11):1674-1688.

BET PROTAC
DOI
PubMed
Success examples
Basophil activation test: Assay precision and BI 1002494 SYK inhibition in healthy and mild asthmatics

Carstensen S., Benediktus E., Litzenburger T., Hohlfeld J. M., Müller M.

Cytometry A 2022, 101(1):86-94.

SYK inhibitor
DOI
PubMed