Success examples
Discovery of Potent SOS1 PROTACs with Effective Antitumor Activities against NCI-H358 Tumor Cells In Vitro/In Vivo

Pang X., Cui D., Lv B., Wang C-Y.

J Med Chem. 2024, 67(2):1563-1579.

SOS1::KRAS inhibitor
DOI
PubMed
Success examples
HIF1α is involved in radiation-induced DNA damage repair and anti-apoptotic pathways in pancreatic ductal adenocarcinoma

Tu K. J., Roy S. K., Sawant A., Shukla H. D.

Cancer Research 2023, Volume 83, Issue 7_Supplement.

KRAS switch I/II pocket inhibitor
DOI
Success examples
The small molecule BI-2852 induces a nonfunctional dimer of KRAS

Tran T. H., Alexander P., Dharmaiah S., Agamasu C., Nissley D. V., McCormick F., Esposito D., Simanshu D. K., Stephen A. G., Balius T. E.

Proc Natl Acad Sci U S A. 2020, 117(7):3363-3364.

KRAS switch I/II pocket inhibitor
DOI
PubMed
Success examples
Glutamine deprivation alters the origin and function of cancer cell exosomes

Fan S. J., Kroeger B., Marie P. P., Bridges E. M., Mason J. D., McCormick K., Zois C. E., Sheldon H., Khalid Alham N., Johnson E., Ellis M., Stefana M. I., Mendes C. C., Wainwright S.M., Cunningham C., Hamdy F. C., Morris J. F., Harris A. L., Wilson C., Goberdhan D. C. 

EMBO J. 2020, 39(16):e103009.

KRAS switch I/II pocket inhibitor
DOI
PubMed