Success examples
Systematic drug profiling across BAF complex perturbations reveals distinct dependencies

Spang K., Barry C., Ntasiou C., Aretaki E., Wolf M., Schumbera E., Kielisch F., Bonn L., Welzel M., Rühle F., Schäfer C., Luck K., Schick S.

bioRxiv 2026, 03.11.710932. Online ahead of print.

Success examples
IAP-based biodegraders can convert necroptosis to apoptosis and eliminate cancer driving protein complexes

Ma X., Vaillant F., Gopal D., Schoffer K., Shojaee F., Pang J., Baldwin C. A., Murphy J. M., Silke J., Tanzer M. C., Visvader J. E., Salvamoser R., Vince J. E.

Cell Chem Biol. 2026, S2451-9456(26)00075-9. Online ahead of print.

Success examples
Tumor metabolic adaptation induced by L-asparaginase reveals a vulnerability to PARP1/2 inhibitor in B-cell lymphomas

Aussel A., Nemazanyy I., Vandenberghe A., Meola P., Dorat N., Paul R., Habbouche L., Exposito L., Nottet N., Petrilli V., Chiche E., Mounier N., Marchetti S., Chaveroux C., Ricci J-E., Chiche J. 

Nat Commun 2026. Online ahead of print.

Success examples
An Allosteric Assay for Identifying Ligands Binding to β2 Adrenergic Receptor by Surface-Enhanced Raman Scattering (SERS)-Active Nanoparticles

Wang Y., Lu N., Wu P., Chu Y., Xing Y., Wang J., Zhao X.

Anal Chem. 2026, 98(6):4895-4904.

Success examples
KAT2A contributes to premature ovarian insufficiency by activating the P38/MAPK signaling pathway to drive granulosa cell dysfunction

Li J., Liu Y., Huang L., Yu Y., Xu A., Luo T., Zheng L., Le M., Xu L.

Biol Reprod. 2026, ioag038. Online ahead of print.

Success examples
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids

van Knippenberg S. S. F. A., Tryfonos M., De Busscher J., Solis M., Lorent C., Girard O., Poovathingal S., Wojno M., Khodeer S., De Clercq J., Mikorska A., Smeers I., Wigerinck E., Meynen Y., Voet T., David L., Van de Velde H., Pasque V.

bioRxiv 2025. 12.01.691499.