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ACBI3 is a first in class VHL-recruiting PROTAC molecule, potently degrading multiple KRAS variants in vitro and in vivo.
BI-9787 is selective ketohexokinase (KHK) inhibitor. It inhibits both the A and C isoforms of KHK with high potency and is suitable for in vitro as well as in vivo studies.
AXPSP0056 is a selective allosteric GCH1 inhibitor that acts as a mimic of tetrahydrobiopterin (BH4). By occupying the latter’s binding site on GCH1, it triggers a feedback inhibition mechanism that decreases GCH1’s activity in the presence of elevated cellular concentrations of BH4.
BI-0474 is a selective and potent irreversible covalent KRASG12C inhibitor, developed using an NMR-based fragment screening approach pioneered at Vanderbilt University, whereby small molecules that bind reversibly to the KRAS switch II pocket were identified and optimized using structu
Orexins are potent neuropeptides interacting with G protein-coupled receptors known as orexin type-1 and type-2 receptors. BI-5121 is a selective orexin type 1 receptor antagonist with high in vitro potency.