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We believe that BI-0319 is a valuable tool to effectively reduce PTK2 protein levels in cell lines to reveal and differentiate between kinase- dependent and -independent functions of PTK2.
BI-1750 is a stable and highly selective intracellular substrate for the human protease Cathepsin C (CatC).1 It can be used to monitor intracellular CatC activity in ex vivo whole blood assays or other cellular systems.
BIII 277CL is a selective high affinity blocker of the NMDA receptor ion channel (Ki = 4.5 nM), which displayed beneficial effects in reducing the cortical infarct area in mice with focal cerebral ischemia.
BI-2051 is a very potent inhibitor of the P. falciparum protease DPAP1. It inhibits recombinant DPAP1 with an IC50 of 0.3 nM and is highly selective versus the homologous human proteases CatC, CatK and CatL (all IC50 > 2500 nM).
BI-9740 is a very potent, highly selective and orally bioavailable CatC inhibitor. BI-9740 shows no species selectivity and displays low nM IC50 in human, mouse and rat CatC assays. BI-9740 has high solubility at pH 2.2, 4.5 and 7.