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BI-1124 is a highly potent inhibitor of the lysosomal cysteine protease Cathepsin S (IC50 7 nM) with a superior pharmacokinetic profile and good selectivity against Cat K, B, and L.
BI-2081 is a partial GPR40 agonist with a good in vitro potency (EC50 = 4 nM) and shows significant anti-hyperglycemic efficacy in vivo.
BI01383298 is a potent inhibitor of SLC13A5 with no structural homology to the substrate for in vitro use. It is selective over other family members (hSLC13A2, hSLC13A3, mSLC13A5) and other transporters. It is offered together with its negative control BI01372674.
BI-0115 is a in vitro tool compound inhibiting oxLDL uptake by the LOX-1 receptor. It is highly selective and provides a unique mechanism of inhibition by stabilizing a receptor tetramer.
Faldaprevir (BI 201335) is a highly potent and selective Hepatitis C Virus (HCV) NS3-NS4A protease inhibitor for pre-clinical research purposes . It is a highly optimized noncovalent competitive inhibitor of NS3-NS4A proteases (HCV genotypes 1a and 1b) with Ki values in the low nanomolar range.