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BI-1046 is a selective and highly potent GPR142 agonist that qualifies for in vivo pharmacology experiments due to its high cellular potency and permeability. A negative control is available (BI-4420).
BI-8925 is a covalent inhibitor of MLKL with a structurally and functionally characterized mode of action and good activity in cells (IC50 = 541 nM).
BIIE0246 is a well-established selective and high affinity non-peptide NPY Y2 receptor antagonist, which proved to be a valuable pharmacological tool in numerous in vitro and in vivo studies.
BI-1915 is a highly potent inhibitor of Cathepsin S (IC50 17 nM) with excellent selectivity against related cathepsins and is therefore a valuable tool for in vitro experiments.
BI-1124 is a highly potent inhibitor of the lysosomal cysteine protease Cathepsin S (IC50 7 nM) with a superior pharmacokinetic profile and good selectivity against Cat K, B, and L.