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BI 605906 is a potent and highly selective inhibitor of IKKβ. In HeLa cells, BI 605906 effectively blocked the phosphorylation of IkBα and the expression of ICAM-1.
BIBR1532 is a highly potent and selective inhibitor of the human telomerase. With excellent permeability and sufficient metabolic stability, it induces telomere shortening and is suitable for both in vitro and in vivo experiments.
ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1. It harnesses the von-Hippel-Landau (VHL) E3 ligase to recruit its targets via their bromodomains.
BI-9321 is a potent and highly selective antagonist of the PWWP1 domain of NSD3. It is a first in class chemical probe, targeting the methyl-lysine binding site, developed in collaboration with the Structural Genomics Consortium (SGC).
The in vitro tool compound BI-2852 is a potent nanomolar inhibitor of the KRAS switch I/II pocket and directly inhibits both the active and inactive forms of KRAS.