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BI-3231 is potent and selective inhibitor of hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13), a lipid droplet-associated enzyme primarily expressed in hepatocytes and whose exact function and substrates are unknown.
BI-9553 is a potent (EC50 < 30 nM in a qPCR cell-based assay), selective, and well-characterized non-nucleoside cytomegalovirus (CMV) polymerase inhibitor. Its cell activity could be dissociated from cytotoxicity depending on different cell lines.
BI-2800 is a highly potent agonist of beta-3 adrenergic receptors. While bound to the latter, it exhibits long residence time and resistance to antagonist activity.
ACBI2 is a highly potent (DC50, 18h, RKO SMARCA2 = 1 nM) and orally bioavailable (Foral, mice = 22%) SMARCA2-VHL PROTAC.
BI-7190 is a probe to study the impact of BPTF bromodomain inhibition in vitro and in vivo. BPTF is a core component of the nucleosome remodelling factor (NURF) complex.