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If you've already used one of our molecules, please leave a review.
The in vitro tool compound BI-2852 is a potent nanomolar inhibitor of the KRAS switch I/II pocket and directly inhibits both the active and inactive forms of KRAS.
BI-3663 is a first in class low molecule weight degrader that tethers a highly selective PTK2 Kinase inhibitor BI-4464 to a CRL4CRBN E3 ubiquitin ligase ligand, aimed at triggering the intracellular destruction of the PTK2 protein.
We believe that BI-0319 is a valuable tool to effectively reduce PTK2 protein levels in cell lines to reveal and differentiate between kinase- dependent and -independent functions of PTK2.
BI-1750 is a stable and highly selective intracellular substrate for the human protease Cathepsin C (CatC).1 It can be used to monitor intracellular CatC activity in ex vivo whole blood assays or other cellular systems.
BIII 277CL is a selective high affinity blocker of the NMDA receptor ion channel (Ki = 4.5 nM), which displayed beneficial effects in reducing the cortical infarct area in mice with focal cerebral ischemia.
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