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If you've already used one of our molecules, please leave a review.
BIBO3304 is a potent and selective in vitro and in vivo tool compound. It acts as an antagonist on the neuropeptide Y (NPY) receptor Y1. Its distomer BIBO3457 is available as negative control.
VUBI1 is a potent activator of SOS1 which modulates the KRAS pathway. SOS1 is a guanine exchange factor that acts as biological control protein for KRAS, one of the most important cellular signaling nodes.
Doramapimod (BIRB 796) is a potent inhibitor of the p38 mitogen activated protein kinase (MAPK). The compound shows anti-inflammatory properties at nanomolar concentrations in cell cultures, which are based on the suppression of TNF-a production.
We share the highly potent and selective SOS1:: KRAS inhibitor BI-3406. The small molecule inhibitor binds to the catalytic site of SOS1, inhibiting the interaction with RAS‐GDP. This significantly reduces formation of GTP-loaded KRAS, thereby inhibiting downstream MAPK signaling.
BI-8668 is a potent and well-characterized epithelial sodium channel (ENaC) inhibitor, for in vitro and in vivo use, structurally distinct from amiloride derived ENaC inhibitors.
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