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BI-7150 is a potent and selective activator of the voltage-gated sodium channel Nav1.1. BI-7283 is available as negative control.
BI-4732 is potent inhibitor against EGFR-activating mutations and on-target resistance mutations. It displays remarkable antitumor efficacy in vitro and in vivo as a single agent, as well as efficient activity in the central nervous system.
ACBI3 is a first in class VHL-recruiting PROTAC molecule, potently degrading multiple KRAS variants in vitro and in vivo.
BI-9787 is selective ketohexokinase (KHK) inhibitor. It inhibits both the A and C isoforms of KHK with high potency and is suitable for in vitro as well as in vivo studies.
AXPSP0056 is a selective allosteric GCH1 inhibitor that acts as a mimic of tetrahydrobiopterin (BH4). By occupying the latter’s binding site on GCH1, it triggers a feedback inhibition mechanism that decreases GCH1’s activity in the presence of elevated cellular concentrations of BH4.