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BI-167107 was used to support crystallization of active state β2AR complexes and can be employed as a tool for the crystallization of other beta receptors.
BI-7273 is a potent dual BRD7/BRD9 inhibitor with 30 fold better potency in the BRD7 AlphaScreen assay compared to our more selective BRD9 inhibitor BI-9564.
BI-9564 binds with high affinity to BRD9 (KD( ITC) = 14 nM), displays good cellular potency and an excellent selectivity versus most BET family members.
BI-4394 is a potent and highly selective inhibitor of MMP-13 that can be used as tool compound to test biological hypotheses in vitro.
BI 831266 is a potent and selective Aurora B inhibitor that inhibits cell proliferation and could be used as a tool compound for testing biological hypotheses.