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mGluR1 PAMs restore cortical inhibitory tone and improve cognition in models of NMDA receptor hypofunction. To support research into mGluR1 function, we offer BI02982816 and its optimized reiteration, BI-1752 — two selective mGluR1 PAMs.
BI-3972 is a potent and selective small-molecule agonist of the calcium-activated potassium channel Slowpoke 1 (SLO-1), which is ubiquitously expressed in metazoans and involved in diverse physiological processes. The structurally related analog BI-4083 serves as a negative control.
BI-0282 is a small molecule antagonist of the MDM2 and p53 protein-protein interaction. BI-0282 shows good permeability and cellular potency and is suitable for oral dosing in in vivo studies.
BI1543673 is a potent and selective IRAK4 inhibitor suitable for both in vitro as well as in vivo use. BI-4326, a structurally close analog, is available as a negative control.
BI-4737 is a Positive Allosteric Modulator (PAM) of the metabotropic glutamate receptor 2 (mGLuR2), a neuronal GPCR negatively coupled to adenylyl cyclase.