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5 June 2025

Discover how open science and free access to high-quality chemical probes helped Steven Johnsen and Thomas Ekstrom at the Robert Bosch Center for Tumor Diseases in Stuttgart / Germany uncover new insights into transcriptional regulation in pancreatic cancer. Read the full interview and get inspired for your own research.

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Molecules for free

2 June 2025

The tumor suppressor protein p53, also known as TP53, is a crucial transcription factor that plays a pivotal role in regulating various cellular processes such as cell cycle arrest, DNA repair, and apoptosis. One of the central molecular control mechanisms of p53 activity and stability is its inhibition through the negative regulator MDM2.

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21 May 2025

Join our live online seminar and learn how open innovation initiatives such as SGC, DCP, and opnMe are enabling academic innovation in cancer research. Hear the full story of our glucocorticoid receptor agonist, BI-653048, and how it helped to unravel the role of the glucocorticoid receptor in pancreatic cancer subtype identity.

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15 April 2025

Boehringer Ingelheim scientists have analysed and published on the impact of structural variants (SVs) on traits related to respiratory, cardiometabolic and liver dieseases. Now we make key data of that study1 available through the opnMe portal to allow unrestricted access by researchers to advance knowledge of genetic variation in the human population.

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14 April 2025

Toll-like receptors (TLRs) are important in initiating inflammatory signaling in the lungs in response to pathogens and environmental triggers. Bacterial lipopolysaccharide (LPS) primarily activates TLR4, while viral stimuli preferentially engage TLR7/8. Previous pre-clinical studies have demonstrated that stimulating TLR4 and TLR7/8 ...

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