79
Molecules for free

20 January 2025

Voltage-gated Na+ channels (Nav1.1 – Nav1.9) are transmembrane proteins involved in the conduction of sodium ions and action potential initiation and propagation. They play a crucial role in the function of excitable tissues in the central nervous system, peripheral nervous system, heart, skeletal muscle, and nociceptive signaling.

54
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02 December 2024

Cancers represent complex ecosystems that include tumor cells and a variety of non-cancerous cells such as immune cells, stroma cells, and other cell types present in the surrounding tissues, all embedded in a modified extracellular matrix. This environment within and around the tumor is known as the tumor microenvironment (TME).

63
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18 November 2024

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that is activated when it binds to ligands from the EGF family. This induces receptor dimerization, tyrosine autophosphorylation, and leads to cell proliferation. It is widely expressed across multiple human tissues, including skin, brain, colon, liver,...

72
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30 September 2024

The Kirsten rat sarcoma viral oncogene homologue (KRAS) is the most mutated oncogene in human cancers. Through opnMe, we offer ACBI3, a first-in-class proteolysis targeting chimera (VHL PROTAC) which arises from a successful collaboration with...

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09 September 2024

The Fms-like tyrosine kinase 3 (FLT3) receptor is expressed by bone marrow progenitors at different stages of lymphoid and myeloid development. When the natural ligand binds to the FLT3 receptor, it triggers receptor dimerization...

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