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Molecules for free

2 June 2025

The tumor suppressor protein p53, also known as TP53, is a crucial transcription factor that plays a pivotal role in regulating various cellular processes such as cell cycle arrest, DNA repair, and apoptosis. One of the central molecular control mechanisms of p53 activity and stability is its inhibition through the negative regulator MDM2.

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12 May 2025

Mental illness affects a significant portion of the global population, with many individuals struggling to find effective treatment. Impulse control dysfunction, characterized by the tendency to act prematurely without foresight, and compulsivity, the urge to perform repetitive behaviors despite adverse results, is a common symptom cluster across various diagnoses.

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24 April 2025

Boehringer Ingelheim scientists have analysed and published on the impact of structural variants (SVs) on traits related to respiratory, cardiometabolic and liver dieseases. Now we make key data of that study1 available through the opnMe portal to allow unrestricted access by researchers to advance knowledge of genetic variation in the human population.

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14 April 2025

Toll-like receptors (TLRs) are important in initiating inflammatory signaling in the lungs in response to pathogens and environmental triggers. Bacterial lipopolysaccharide (LPS) primarily activates TLR4, while viral stimuli preferentially engage TLR7/8. Previous pre-clinical studies have demonstrated that stimulating TLR4 and TLR7/8 ...

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07 April 2025

Boehringer Ingelheim Animal Health (BIAH) is dedicated to improving animal health by understanding the drivers of chronic inflammation in canine periodontitis. Canine periodontitis is a common oral disease in dogs characterized by inflammation and destruction of the periodontal tissues, leading to tooth loss and potential systemic health implications.

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