0
Molecules for free

16 March 2026

TRPC4 and TRPC5 are members of the transient receptor potential canonical (TRPC) family of non-selective cation channels, key regulators of neuronal excitability. To incentivize new research into TRPC4/5 biology in the context of diseases, we offer HC-070, a potent and selective inhibitor of the TRPC4/5 cation channels free of charge to scientists.

5
Molecules for free

2 March 2026

Predominantly expressed and active in immune cells, PI3Kγ plays a crucial role in regulating intracellular pathways like chemotaxis, inflammatory activation, and effector functions. By making our potent and selective PI3Kγ inhibitor, BI-9222, available to scientists free of charge, we incentivize new research with this molecule in the context of diseases.

17
Collaborate with us

26 January 2026

Nociplastic pain, a subtype of chronic pain, arises from altered nociception in the absence of clear tissue damage. Its poorly understood pathogenesis and the limited efficacy of current treatments underscore the urgent need for identifying and validating innovative pharmacological approaches that target central neurobiological pathways involved in pain processing.

23
Collaborate with us

9 January 2026

We now share a well-characterized small molecule inhibitor of ALPK1, BI-4286, to dissect the molecular mechanisms underlaying ALPK1 signaling in disease pathology. The focus is on select indications outside of ROSAH syndrome and infectious diseases. Submit your research proposal for a chance to access BI-4286 and receive funding.

24
Collaborate with us

1 December 2025

Nociplastic pain, a subtype of chronic pain, arises from altered nociception in the absence of clear tissue damage. Its poorly understood pathogenesis and the limited efficacy of current treatments underscore the urgent need for identifying and validating innovative pharmacological approaches that target central neurobiological pathways involved in pain processing.

Discover us

Hear from our collaborators