9
Molecules for free

8 September 2025

Positive allosteric modulators of mGluR1 restore cortical inhibitory tone and improve cognitive performance in models of NMDA receptor hypofunction. To support ongoing research into mGluR1 function, we now offer two highly selective positive allosteric modulators of mGluR1: BI02982816 and its chemically optimized reiteration, BI-1752.

28
Molecules for free

30 June 2025

The Slowpoke 1 (SLO-1) channel is a large-conductance calcium- and voltage-activated potassium channel and a homotetrameric member of the evolutionarily conserved K+ channel family. Activated by cellular depolarization and cytosolic calcium, SLO-1 plays a critical role in regulating cell excitability and neurotransmitter release.

10
Molecules for free

2 June 2025

The tumor suppressor protein p53, also known as TP53, is a crucial transcription factor that plays a pivotal role in regulating various cellular processes such as cell cycle arrest, DNA repair, and apoptosis. One of the central molecular control mechanisms of p53 activity and stability is its inhibition through the negative regulator MDM2.

25
PostDoc Grants

19 May 2025

Assessing the environmental persistence of active pharmaceutical ingredients (APIs) is crucial for minimizing the ecological footprint across every stage of a medicine's lifecycle. Boehringer Ingelheim Animal Health prioritizes sustainability by integrating frameworks like Safe and Sustainable by Design (SSbD) and Green Chemistry Principles into parasiticide drug design, mirroring human pharmaceutical development processes encompassing hit finding, lead optimization, and candidate development.

55
Molecules for free

14 April 2025

Toll-like receptors (TLRs) are important in initiating inflammatory signaling in the lungs in response to pathogens and environmental triggers. Bacterial lipopolysaccharide (LPS) primarily activates TLR4, while viral stimuli preferentially engage TLR7/8. Previous pre-clinical studies have demonstrated that stimulating TLR4 and TLR7/8 ...

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