3
Collaborate with us

17 November 2025

A large portion of the proteome remains “undruggable” with traditional small molecules and biologics. To expand the druggable target landscape in areas of high unmet medical needs, novel innovative approaches could focus on targeting intracellular mechanisms, such as influencing nuclear translocation, organelle routing, molecular condensates, and spatial-temporal control mechanisms.

12
Collaborate with us

20 October 2025

The Boehringer Ingelheim ChemKit initiative, provides open access to high-quality, structurally diverse, and drug-relevant building blocks. These structurally diverse building blocks enable the validation of novel chemical transformations in complex synthesis, stimulating research on innovative methodologies to overcome current limitations in chemical science.

27
Molecules for free

9 October 2025

opnMe now offers 100 well-characterized preclinical molecules for free to researchers worldwide. Since 2017, the program has supported over 10,000 orders from 54 countries, contributing to more than 240 scientific publications and advancing research across various fields. Explore the full collection of molecules today.

10
Molecules for free

6 October 2025

Vanin 1 and vanin 2 regulate cellular redox homeostasis and play key roles in maintaining oxidative balance and modulating inflammation. To advance further exploration, we offer BI-4122, a dual vanin 1/2 inhibitor. BI-4122 is optimized for intravenous and oral administration and comes along with BI-9534, an inactive control, to enable robust experimental designs.

12
Collaborate with us

22 September 2025

Fibrosis plays a pivotal role in endometriosis disease progression and associated pelvic pain. Targeting fibrosis in endometriotic lesions may represent a promising therapeutic strategy. However, current preclinical models fail to replicate the chronic fibrosis observed in humans, limiting our ability to fully understand the disease mechanisms.

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