5
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22 September 2025

Fibrosis plays a pivotal role in endometriosis disease progression and associated pelvic pain. Targeting fibrosis in endometriotic lesions may represent a promising therapeutic strategy. However, current preclinical models fail to replicate the chronic fibrosis observed in humans, limiting our ability to fully understand the disease mechanisms.

5
Molecules for free

8 September 2025

Positive allosteric modulators of mGluR1 restore cortical inhibitory tone and improve cognitive performance in models of NMDA receptor hypofunction. To support ongoing research into mGluR1 function, we now offer two highly selective positive allosteric modulators of mGluR1: BI02982816 and its chemically optimized reiteration, BI-1752.

27
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26 August 2025

GPR149, an orphan G-protein coupled receptor, might be a promising therapeutic target for psychiatric and obesity-related disorders. Despite its conserved expression across mammalian species, its physiological and functional roles remain poorly understood. Notably, GPR149 is predominantly expressed in the brain, with high levels in regions such as the basal ganglia, which regulate motivation, emotion, and impulsivity—key pathways implicated in psychiatric disorders.

23
Molecules for free

30 June 2025

The Slowpoke 1 (SLO-1) channel is a large-conductance calcium- and voltage-activated potassium channel and a homotetrameric member of the evolutionarily conserved K+ channel family. Activated by cellular depolarization and cytosolic calcium, SLO-1 plays a critical role in regulating cell excitability and neurotransmitter release.

14
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16 June 2025

Obesity is a highly prevalent, complex, chronic disease associated with cardiometabolic complications, including type 2 diabetes, hypertension, dyslipidemia, and cardiovascular disease. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) analogues such as semaglutide and tirzepatide have achieved clinically relevant body weight reduction among adults with overweight/obesity.

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